| Andie MacDowell (Ann Finnigan) |
| Bruce Davison (Howard Finnigan) |
| Jack Lemmon (Paul Finnigan) |
| Zane Cassidy (Casey Finnigan) |
| Julianne Moore (Marian Wyman) |
| Matthew Modine (Le Dr. Ralph Wyman) |
| Anne Archer (Claire Kane) |
| Fred Ward (Stuart Kane) |
| Jennifer Jason Leigh (Lois Kaiser) |
| Chris Penn (Jerry Kaiser) |
| Joseph C. Hopkins (Joe Kaiser) |
| Josette Maccario (Josette Kaiser) |
| Lili Taylor (Honey Bush) |
| Robert Downey Jr. (Bill Bush) |
| Madeleine Stowe (Sherri Shepard) |
| Tim Robbins (Gene Shepard) |
| Cassie Friel (Sandy Shepard) |
| Dustin Friel (Will Shepard) |
| Austin Friel (Austin Shepard) |
| Lily Tomlin (Doreen Piggot) |
| Tom Waits (Earl Piggot) |
| Frances McDormand (Betty Weathers) |
| Peter Gallagher (Stormy Weathers) |
| Jarrett Lennon (Chad Weathers) |
| Annie Ross |
| Lori Singer |
| Lyle Lovett (Andy Bitkower) |
| Buck Henry (Gordon Johnson) |
| Huey Lewis (Vern Miller) |
| Danny Darst (Aubrey Bell) |
| Margerie Bond (Dora Willis) |
| Robert Do'Qui (Knute Willis) |
| Darnell Williams (Joe Robbins) |
| Michael Beach (Jim Stone) |
| Andi Chapman (Harriet Stone) |
| Deborah Falconer (Barbara) |
| Susie Cusack (Nancy) |
| Charles Rocket (Wally Littleton) |
| Jane Alden (Mme Schwartzmeier) |
| Christian Altman (Jimmy Miller) |
| Willie Marlett (Un ami de Jimmy Miller) |
| Dirk Blocker |
| Suzanne Calvert |
| Natalie Strong |
| Jay Della |
| Jeruth Persson |
| Derek Webster |
| Nathaniel H. Harris III |
| Alex Trebek (Lui-même) |
| Jerry Dunphy (Lui-même) |
| Terry Adams |
| Bobby Previte |
| Greg Cohen |
| Gene Estes |
| Bruce Fowler |
| Stuart Canin |
| Anatoly Rosinsky |
| Roland Kato |
| Armen Guzelimian |
| Damon Charles |
| Michael Hollander (Le fils de Knute Willis) |
| Sergio Kato (Lui-même) |
| Daisy Kramer |
| Andrew Levinson |
| Ron McPherson |
| Derek Raser (Le pilote de l'hélicoptère) |
| Pamela Roth |
| Dani Shear |
| Ken Twohy |