| Al Pacino (Benjamin "Lefty" Ruggiero) |
| Johnny Depp (Donnie Brasco / Joseph D. "Joe" Pistone) |
| Michael Madsen (Sonny Black) |
| Bruno Kirby (Nicky) |
| James Russo (Paulie) |
| Anne Heche (Maggie) |
| Željko Ivanek (Tim Curley) |
| Gerry Becker (Dean Blandford) |
| Robert Miano (Sonny Red) |
| Brian Tarantina (Bruno) |
| Rocco Sisto (Richard "Richie" Gazzo) |
| Zach Grenier (Le Dr. Berger) |
| Walt MacPherson (Le shériff) |
| Ronnie Farer (Annette) |
| Terry Serpico |
| Gretchen Mol |
| Tony Lip (Philly Lucky) |
| George Angelica |
| Val Avery |
| Madison Arnold (Jilly) |
| Delanie Fitzpatrick |
| Katie Sagona |
| Sara Gold |
| Larry Romano (Tommy) |
| Tim Blake Nelson |
| Paul Giamatti |
| James Michael McCauley |
| Jim Bulleit |
| Andrew Parks (Hollman) |
| Keenan Shimizu |
| Rocco Musacchia |
| Joe Francis |
| Sal Jenco |
| Billy Capucilli |
| Laura Cahill |
| Doreen Murphy |
| Elle Alexander |
| Denise Faye |
| Elaine del Valle |
| John Horton |
| Dan Brennan |
| LaJuan Carter |
| Sandy Barber |
| Joyce Stovall |
| Frank Pesce |
| Randy Jurgensen |
| John DiBenedetto |
| Richard Zavaglia |
| Tony Ray Rossi |
| Edward Black |
| Gaetano LoGiudice |
| Carmelo Musacchia |
| Pat Vecchio |
| Caleb |
| Flint Beverage |
| Frank Bonsangue |
| Mark Todd Bruner |
| Frankie Cee |
| Gregory d'Angelo |
| Christopher del Gaudio |
| Stephen Emirzian |
| Teresa Giudice |
| Barry Hirschberg |
| Jim Lavin (Un officier du FBI lors de l'arrestation) |
| Jeff Millstein |
| James Morricone |
| Peter O'Hara |
| Davell j Owens |
| Antone Pagán |
| Lisa Panagos |
| Garry Pastore |
| Felicia Peluso |
| Frank Pietrangolare (Un garde du corps) |
| Dale Resteghini |
| Joseph Rigano |
| Larry Tobias |
| Vinny Vella |
| Edward Williams |