| Kevin Costner (Wyatt Earp) |
| Gene Hackman (Nicholas Earp) |
| Dennis Quaid (John 'Doc' Holliday) |
| Isabella Rossellini (Kate 'Gros Nez') |
| Tom Sizemore (Bat Masterson) |
| Bill Pullman (Ed Masterson) |
| David Andrews (James Earp) |
| Jeff Fahey (Ike Clanton) |
| Michael Madsen (Virgil Earp) |
| Annabeth Gish (Urilla Sutherland) |
| Mark Harmon (Johnny Behan) |
| Jim Caviezel (Warren Earp) |
| Adam Baldwin (Tom McLaury) |
| Téa Leoni (Sally) |
| Norman Howell (Johnny Ringo) |