| Tom Hanks (Viktor Navorski) |
| Catherine Zeta-Jones (Amelia Warren) |
| Stanley Tucci (Frank Dixon) |
| Chi McBride (Mulroy) |
| Diego Luna (Enrique Cruz) |
| Barry Shabaka (Henley Thurman) |
| Kumar Pallana (Gupta Rajan) |
| Zoë Saldana (Dolores Torres) |
| Eddie Jones (Salchak) |
| Jude Ciccolella (Karl Iverson) |
| Corey Reynolds (Waylin) |
| Guillermo Diaz (Bobby Alima) |
| Rini Bell (Nadia) |
| Stephen Mendel (Le steward de la première classe) |
| Valera Nikolaev (Milodragovich) |
| Michael Nouri (Max) |
| Ana Maria Quintana (Un inspecteur) |
| Bob Morrisey (Un inspecteur) |
| Sasha Spielberg (Lucy) |
| Cas Anvar |