| Robert Downey Jr. (Sherlock Holmes) |
| Jude Law (Le Dr. John Watson) |
| Rachel McAdams (Irene Adler) |
| Mark Strong (Lord Henry Blackwood) |
| Eddie Marsan (L'inspecteur Lestrade) |
| Robert Maillet (Dredger) |
| Geraldine James (Mme Hudson) |
| Kelly Reilly (Mary Morstan) |
| William Houston (Constable Clark) |
| Hans Matheson (Lord Coward) |
| James Fox (Sir Thomas Rotheram) |
| William Hope (L'ambassadeur Standish) |
| Clive Russell (Le capitaine Tanner) |
| Oran Gurel (Reordan) |
| David Garrick (McMurdo) |
| Kylie Hutchinson |
| Andrew Brooke (Le capitaine des gardes) |
| Tom Watt |
| John Kearney |
| Sebastian Abineri |
| Jonathan Gabriel Robbins (Un garde) |
| James A. Stephens (Le capitaine Philips) |
| Terry Taplin |
| Bronagh Gallagher |
| Ed Tolputt |
| Joe Egan |
| Jefferson Hall |
| Miles Jupp |
| Marn Davies |
| Andrew Greenough (Un garde de la prison) |
| Ned Dennehy (L'homme avec des roses) |
| Martin Ewens |
| Amanda Grace Johnson |
| James Greene (Le gouverneur) |
| David Emmings |
| Ben Cartwright |
| Chris Sunley |
| Michael Jenn (Le prêtre) |
| Timothy O'Hara |
| Guy Williams |
| Peter Miles |
| Sharon Ashton |
| William Atkinson |
| Paul Bateman (Un prisonnier) |
| Kathryn Beaumont |
| Aidan Belizaire |
| Jonathan Bridge |
| Kenneth W. Caravan |
| Alan Carter |
| Kenneth Coombs |
| Radu Andrei Cucu |
| James Currie |
| Paul J. Dove |
| Jasey Ó Dálaigh (Michael) |
| Andrew Goldfarb |
| Kas Graham |
| Michael Hennessy |
| Marc Hockley |
| Thomas Kadman |
| Bobby Leigh |
| Brendan McCoy |
| Terence Pickering |
| Matthew Radway |
| Rocco Ritchie (Un enfant dans la rue) |
| Bryan Samson |
| Robert Stone |
| David Swift |
| John Warman (Un policier) |