| Christina Ricci (Penelope Wilhern) |
| James McAvoy (Johnny / Max) |
| Reese Witherspoon (Annie) |
| Peter Dinklage (Lemon) |
| Catherine O'Hara (Jessica Wilhern) |
| Richard E. Grant (Franklin Wilhern) |
| Simon Woods (Edward Humphrey Vanderman III) |
| Ronni Ancona (Wanda) |
| Jason Thornton (Shane) |
| Paul Herbert (Leonard Wilhern) |
| Nicholas Prideaux (L'arrière grand-père de Penelope) |
| Michael Feast (Jake / Witch) |
| Simon Chandler (Le médecin) |
| Andi-Marie Townsend (Penelope jeune) |
| John Voce (Un policier) |
| Burn Gorman (Larry) |
| Andrew Bailey |