| Robert Downey Jr. (Sherlock Holmes) |
| Jude Law (Le Dr. John Watson) |
| Rachel McAdams (Irene Adler) |
| Eddie Marsan (L'inspecteur Lestrade) |
| Kelly Reilly (Mary Watson) |
| Noomi Rapace (Madame Simza Heron) |
| Jared Harris (Le Pr. James Moriarty) |
| Stephen Fry (Mycroft Holmes) |
| Paul Anderson (Le colonel Sebastian Moran) |
| Geraldine James (Mme Hudson) |
| William Houston (Constable Clark) |
| Wolf Kahler (Le Dr. Hoffmanstahl) |
| Iain Mitchell |
| Jack Laskey |
| Patricia Slater |
| Karima Adebibe |
| Richard Cunningham |
| Marcus Shakesheff |
| Mark Sheals |
| George Taylor |
| Michael Webber |
| Mike Grady (Le conducteur du train) |
| Alexandre Carril (Un des jumeaux) |
| Victor Carril (Un des jumeaux) |
| Thorston Manderlay (Alfred Meinhard) |
| Afif Ben Badra (Tamas) |
| Daniel Naprous (Marko) |
| Lancelot Weaver (Stefan) |
| Vladimir Furdik (Andrzej) |
| Jacques Senet Larson |
| Nicolas Senet Larson |
| Sebastian Senet Larson |
| Alexander Devrient |
| Fatima Adoum |
| Stanley Kaye (Stanley) |
| Thierry Neuvic (Claude Ravache) |
| Martin Nelson |
| Mark Llewelyn-Evans (Don Giovanni) |
| Anthony Inglis |
| Ian Wilson-Pope (Leporello) |
| Pamela Hay (Elvira) |
| Laurence Dobiesz |
| Peter Stark (Un officier allemand) |
| Roman Jankovic (Un officier allemand) |
| Frederick Ruth |
| Carsten Hayes |
| Jonathan Christie (Un diplomate) |
| James McNeill (Un diplomate) |
| Laurentiu Possa (Rene Heron) |
| Maitland Chandler |
| Joe Egan (Big Joe) |
| Clive Russell (Le capitaine Tanner) |
| Lasco Atkins |
| D. J. Bailey (Le premier ministre Robert Cecil) |
| Paul Bateman |
| Chris Capaldi |
| Kenneth Coombs |
| Gioacchino Jim Cuffaro |
| Lukas DiSparrow |
| Ray Donn (Un diplomate) |
| Ross Egan (Le leader anarchiste français) |
| Rich Goble |
| Shonn Gregory (George) |
| Marina Hayter |
| Michael Hennessy |
| Marc Hockley |
| Jefferson King |
| Jeff Lipman (Un diplomate) |
| Steve Munroe |
| Kerry Rousell |
| Mark Sealey |
| Danny Seldon (Le roi George de Grèce) |
| Alain Stash |
| Tom Swacha |
| Charles Walters |
| Paul Warren |
| Christian Wolf-La'Moy |