| Ioan Gruffudd (Red Richards / Monsieur Fantastic) |
| Jessica Alba (Sue Storm / La femme invisible) |
| Chris Evans (Johnny Storm / La torche humaine) |
| Michael Chiklis (Ben Grimm / La chose) |
| Julian McMahon (Victor Fatalis / VO : Victor von Doom) |
| Hamish Linklater (Leonard) |
| Kerry Washington (Alicia Masters) |
| Laurie Holden (Debbie McIlvane) |
| David Parker (Ernie) |
| Kevin McNulty (Jimmy O'Hoolihan) |
| Maria Menounos |
| Michael Kopsa (Ned Cecil) |
| Andrew Airlie |
| Pascale Hutton |
| G. Michael Gray |
| David Richmond-Peck |
| Penelope Corrin |
| Aonika Laurent |
| Jason Schombing |
| Jason Diablo (Un policier de la NYPD sur le pont) |
| Colin Lawrence (Un policier de la NYPD sur le pont) |
| Paul Belsito (Un policier de la NYPD sur le pont) |
| Deejay Jackson (Le chef des pompiers) |
| Morgan Reynolds |
| Gina Holden |
| Donavon Stinson |
| Douglas Weston (Le docteur de Victor) |
| Tony Alcantar |
| Brenda Crichlow |
| Peter Bryant |
| Lorena Gale |
| Danielle Dunn-Morris |
| Nicole Munoz |
| Daniel Bacon (Un reporter sur le pont) |
| Bobbi Bysouth |
| Kenny Bartram |
| Ronnie Renner (Lui-même) |
| Brian Deegan |
| Marlaina Mah |
| Tre Verhoeven |
| Juanita Mirehouse |
| Stefanie Singer |
| Jamie Little |
| Doug Abrahams |
| Ron Chartier |
| Stan Lee (Willie Lumpkin) |
| Barbara Christabella |
| Sanja Banic |
| Ed Hodson |
| John Speredakos |
| Jason Kaufman (Un policier) |
| Preston Peet (Le type gothique) |
| Steven Fulani Hart |
| Bethann Schebece |
| Lou Torres |
| Peggy Gormley |
| Maurice Tyson |
| Jaimie McVittie (La petite fille sur le pont) |
| Jenni Squair |
| Lia Salmond |
| Ellen Ewusie |
| Ylenia Aurucci |
| Michelle Kulas |
| Kate Mullan |
| Georgia Dewson |
| Sienna Rose (Une fan de Storm) |
| Hector A. Leguillow |
| Benedict Mulroney |
| Terry David Mulligan |
| Lauren Sanchez |
| Mark S. Allen |
| Jon Brady |
| Taryn Winter Brill |
| Sara Edwards |
| Heidi Eng |
| Jim Ferguson |
| CB Hackworth |
| Sam Hallenbeck |
| Mike Waco |
| Marian Etoile Watson |
| Richard Ho |
| Dave Holmes |
| Andrew Hunsaker |
| Taylor Johnson |
| Bonnie Laufer-Krebs |
| Jennifer Lothrop |
| Lisa Fuller Magee |
| Bret Martin |
| Liam Mayclem |
| Scott Patrick |
| Shaheem Reid |
| Sam Rubin |
| Maria Salas |
| Devon Soltendieck |
| Patrick Stoner |
| Lee Thomas |
| Anthony Toscano |
| David Moss |
| Lorna Joan Barrie (Une femme sur le pont) |
| Sean Bennett |
| Todd Carroll |
| Douglas Chapman |
| Sandra-Jessica Couturier |
| Rhys Edwards |
| Christopher Gordon |
| Vivian Kalinov |
| Yvonne Myers |
| Mashiah Vaughn-Hulbert |
| Ralph Winter |
| Lynnanne Zager (La voix VO de l'ordinateur) |