| Tom Holland (Peter Parker / Spider-Man) |
| Michael Keaton (Adrian Toomes / Le Vautour) |
| Robert Downey Jr. (Tony Stark / Iron Man) |
| Marisa Tomei (May Parker) |
| Jacob Batalon (Ned Leeds) |
| Zendaya (Michelle) |
| Laura Harrier (Liz) |
| Jon Favreau (Happy Hogan) |
| Gwyneth Paltrow (Pepper Potts) |
| Donald Glover (Aaron Davis) |
| Tony Revolori (Flash) |
| Bokeem Woodbine (Herman Schultz) |
| Tyne Daly (Anne Marie Hoag) |
| Abraham Attah (Abe) |
| Hannibal Buress (Le coach Wilson) |
| Kenneth Choi (Principal Morita) |
| Selenis Leyva (Ms. Warren) |
| Angourie Rice (Betty) |
| Martin Starr (Mr. Harrington) |
| Garcelle Beauvais (Doris Toomes) |
| Michael Chernus (Phineas Mason) |
| Michael Mando (Mac Gargan) |
| Logan Marshall-Green (Jackson Brice) |
| Jennifer Connelly (Karen) |
| Gary Weeks (L'agent Foster) |
| Christopher Berry (Randy) |
| Jorge Lendeborg Jr. (Jason) |
| Tunde Adebimpe (Mr. Cobbwell) |
| Tiffany Espensen (Cindy) |
| Isabella Amara (Sally) |
| Michael Barbieri (Charles) |
| J. J. Totah (Seymour) |
| Hemky Madera (Mr. Delmar) |
| Zach Cherry (Le vendeur dans la rue) |
| Kirk Thatcher (Le punk dans la rue) |
| Yu Lew |
| Sondra James |
| Bob Adrian |
| Gary Richardson |
| Stan Lee (Gary) |
| Joe Hang |
| Wayne Pére (Le prof d'histoire) |
| Chris Evans (Steve Rogers / Captain America) |
| Alexa Laraki |
| Liza Fagin |
| Kerry Condon |
| John Penick (Mr. Hapgood) |
| Ethan Dizon |
| Amy Hill |
| Miles Mussenden |
| Martha Kelly |
| Kevin N. LaRosa |
| Ren Colley |
| Jennifer Kim |
| Ari Groover |
| Louis Gonzalez |
| Stewart Steinberg |
| Andy Powers |
| Omar Capra |
| Nitin Nohria (Dean Crimson) |
| Vince Foster |
| Brian Schaeffer |
| Chris Adams |
| Mary Liz Adams (L'amie de Liz) |
| John Jacob Anderson (Un touriste allemand) |
| Myles Anderson |
| Nicholas Azarian |
| Cassidy Balkcom |
| Isabelle Ballard |
| Sydney Shea Barker |
| Romar Bennett |
| Jb Blaine |
| Tristian Blair |
| Maiya Boyd |
| Dante Brattelli |
| Michael Breath |
| Lauren Brumbelow |
| Randy Burnett |
| David Cao |
| Liam Capek |
| London Carlisle |
| Friday Chamberlain |
| Chuck Chapman |
| Tony F. Charles |
| Leonardo Collaguazo |
| Richard R. Corapi |
| Marmee Regine Cosico |
| Joy Costanza |
| Roy Coulter |
| Rebeca Donovan |
| Elli |
| Adrian Favela |
| Michelle Fisichella |
| Gregory French |
| Tahseen Ghauri |
| Davvy Glab (Un photographe) |
| Melissa Kay Glaze |
| Austin Handle |
| Madison Hine |
| Jonathan Randall Hunter |
| Bailey Ingersoll |
| Jada Jarvis |
| Jerome Joyce |
| Wesley Kuykendoll |
| Scott Lane |
| Michael Layman |
| Zachary Leipert |
| Lenny Lenox (Un agent du S.H.I.E.L.D.) |
| Faith Logan |
| Destiny Lopez (Un technicien de Tony Stark) |
| Sherin Maldonado |
| Faith Monique |
| Melvin Kindall Myles |
| Darshan Patel |
| Felix Perez |
| Mason Pike |
| Calvin Powell |
| Hallie Ricardo |
| Hunter Romanillos |
| Mario Romano |
| Juana Samayoa |
| Jill Savel |
| Patti Schellhaas |
| Doug Scroggins III |
| Chris Sepulveda (Le père de Ned) |
| Mike Sibley |
| Chris Silcox |
| Stephen Vining |
| Kent Wagner |
| Megan Wilkens |
| Rachel Star Withers |
| Nickolas Wolf |
| Trevor Wolf |
| Tiani Wright |