| Benedict Cumberbatch (Sherlock Holmes) |
| Martin Freeman (Le docteur John Watson) |
| Rupert Graves (Lestrade) |
| Mark Gatiss (Mycroft Holmes) |
| Andrew Scott (Jim Moriarty) |
| Vinette Robinson (Le sergent Sally Donovan) |
| Tanya Moodie (Ella) |
| John Lebar (Golem) |
| Una Stubbs (Madame Hudson) |
| Siobhan Hewlett (Helen) |
| Loo Brealey (Molly Hooper) |
| Victoria Wicks (Margaret Patterson) |
| William Scott-Masson (Sir Jeffrey Patterson) |
| San Shella (Alan West) |
| James Duncan (Jimmy) |
| Lauren Crace (Lucy) |
| Doug Allen (Joe) |